PROJECT SUMMARY/ABSTRACT: The Biostatistics, Bioinformatics and Patient Registry Core provides statistical and bioinformatics collaboration and data management support for each of the SPORE Projects and the research projects initiated through the Breast Cancer SPORE Developmental Research Program and the Career Enhancement Program. Each project has a biostatistician and/or bioinformatician embedded into its research team with the breast cancer content knowledge to understand the central hypothesis being tested and the analytic expertise to ensure the development of a study design which can generate data to address the questions posed as well as ensure the application of or development of statistical and bioinformatics analysis techniques that are appropriate to assess the central hypothesis.