# Gammaherpesviral interactions with the host cell

> **NIH NIH P01** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2022 · $347,154

## Abstract

Project 3
Project Summary Abstract
Globally, oncogenic DNA viruses cause a significant cancer burden. These viruses establish life-long
persistence in the human host and are associated with the development of epithelial, endothelial, and B cell
cancers. The human gammaherpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated virus
(KSHV) are associated with B cell lymphomas, Kaposi’s sarcoma, gastric cancer, and nasopharyngeal
carcinoma (NPC). Moreover, human papillomavirus (HPV) is associated with oropharyngeal and cervical
carcinoma.
In this application, we propose to explore how the oncogenic gammaherpesviruses, KSHV and EBV, modulate
cellular pathways including adenosine-related signaling pathways and how they contribute to oncogenesis.
Investigating the various mechanisms involved in modulation of host immunity and oncogenesis by these
tumor viruses will inform our understanding of the biology and pathogenesis of these viruses. Our findings will
also pave the way for future therapies to treat virus-associated cancers.

## Key facts

- **NIH application ID:** 10495575
- **Project number:** 2P01CA019014-42A1
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** BLOSSOM A DAMANIA
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $347,154
- **Award type:** 2
- **Project period:** 1997-05-01 → 2027-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10495575

## Citation

> US National Institutes of Health, RePORTER application 10495575, Gammaherpesviral interactions with the host cell (2P01CA019014-42A1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10495575. Licensed CC0.

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