Core B: Vironomics and Biostatistics Core Project Summary Abstract This is a renewal application of a long-standing P01 grant. Core B provides Next Generation Sequencing, bioinformatic and biostatistics capabilities that are specific to viral genomics and that are unique among US investigators. It is used by all projects. Core B houses both physical instrument and specialized expertise, such as dedicated Oxford Nanopore and Ion Torrent sequencers (S5 and Genexus), a BD Rhapsody single-cell sequencing instrument, a project specific high-compute server and full-time programmer. This will ensure that this long-standing VPP remains at the cutting edge in terms of technical innovation in tumor virology.