# Core B - Animal Vascular-Metabolic-Neural Network Core

> **NIH NIH P01** · UNIVERSITY OF KENTUCKY · 2022 · $645,879

## Abstract

CORE B - ABSTRACT
The goals of the Mouse VMN (vascular, metabolism, network) Core B are to serve the P01 Projects with cutting-
edge methods specifically tailored to the P01 themes: Strategies for Targeting Astrocyte Reactivity in AD and
ADRD (STAR-AD-ADRD). Astrocytes support brain function by integrating their roles with several cell types.
They support neurons and regulate blood flow to supply and preserve active brain regions. Astrocytes become
reactive in Alzheimer’s disease (AD) and Alzheimer’s disease related dementias (ADRD) and their functions are
not fully understood. Our group at the Sanders-Brown Center on Aging including Drs. Wilcock, Thibault, Norris,
and Nelson investigate roles of astrocytes, neurons and vascular pathology in aging and AD/ADRD brain. These
research topics are inter-connected and the success of this P01 will move our understanding of reactive
astrocytes beyond neuroinflammation constraints. Our VMN Core will provide multiple approaches to
characterize the roles of reactive astrocytes on cerebrovascular function, brain metabolism and neuronal network
activity. Moreover, results uniformly generated from our core will permit useful comparisons across projects. The
Specific aims are to: (1) Coordinate for small animal surgeries and intravital imaging techniques, including
training and oversight. (2) Coordinate all brain slice electrophysiology experiments. (3) Coordinate and provide
service for microelectrode array experiments. (4) Coordinate and provide service for Magnetic Resonance
Imaging experiments. Furthermore, our Core will work with the DMB (Data Management and Biostatistics)
Core D, where the results will be stored, processed and easily accessed from our collaborative groups both in
UK and beyond.

## Key facts

- **NIH application ID:** 10495932
- **Project number:** 1P01AG078116-01
- **Recipient organization:** UNIVERSITY OF KENTUCKY
- **Principal Investigator:** Pradoldej Sompol
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $645,879
- **Award type:** 1
- **Project period:** 2022-09-01 → 2027-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10495932

## Citation

> US National Institutes of Health, RePORTER application 10495932, Core B - Animal Vascular-Metabolic-Neural Network Core (1P01AG078116-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10495932. Licensed CC0.

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