# Healthspan Core

> **NIH NIH P01** · YALE UNIVERSITY · 2022 · $582,993

## Abstract

Core B: Project Summary:
The objective of Core B (Mouse Aging Analysis Core ) is to provide a centralized core facility for the PPG at
the Yale School of Medicine that will generate and analyze transgenic mouse models to determine the roles of
local adipose FGF21 on lifespan extension and age-related functional decline across multiple systems. The
Core B will allow the PPG to gain mechanistic insights into the pro-longevity effects of local FGF21 and role of
augmentor-α-ALK signaling, across multiple organ systems (adipose tissue, liver, bone, CNS and the immune
system) using measures of functional decline in aging, longevity and burden of disease as primary endpoints.
The Aim 1 of Core B is be work closely with the leader of the Administrative Core and leaders of the research
projects, to assist in the experimental design and execution of the animal research phase of the individual
projects, and to assure efficiency and standardization of procedures. Aim 2: To complete the omnibus study
with male and female mice examining the effect of adipose specific inducible overexpression of FGF21 on
lifespan. Aim 3: To determine the impact of FGF-21 superagonist (FGF21SA) on lifespan, inflammaging and
healthspan. Aim 4: To perform healthspan analyses of mice with overexpression of FGF21 mouse in
augmentor-α knockout models.

## Key facts

- **NIH application ID:** 10496166
- **Project number:** 2P01AG051459-06
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** VISHWA DEEP DIXIT
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $582,993
- **Award type:** 2
- **Project period:** 2016-09-15 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10496166

## Citation

> US National Institutes of Health, RePORTER application 10496166, Healthspan Core (2P01AG051459-06). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10496166. Licensed CC0.

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