PROJECT SUMMARY/ABSTRACT – Administrative Core The purpose of the Administrative Core (Core A) is to support the translational objectives of the UCLA SPORE in Brain Cancer by serving as its organizational hub. The Core is responsible for the oversight and daily functions of the SPORE and provides organizational, administrative, and scientific leadership (both basic and clinical) for all of the aspects of the SPORE, including coordination and communication between all investigators and committee members. It will provide scientific management, including ongoing oversight and scientific review of all projects and cores to ensure that the stated scientific goals of the SPORE are met. The Core has ultimate responsibility for the overall financial management of the budget and appropriate filing of budgetary information. It will organize regularly scheduled meetings and seminars, and provide commitment of SPORE investigators to attend the annual NCI Brain SPORE Mid-Winter Retreat and other relevant NCI-related meetings/workshops and activities. The scheduling and organization of an annual UCLA Brain Cancer SPORE Symposium, including participation of the External Advisory Board (EAB), will be the responsibility of the Administrative Core. This Core will oversee the administration of the SPORE Developmental Research (DRP) and Career Enhancement Programs (CEP), while providing oversight and assuring compliance with all UCLA, NCI, and Federal regulations and requirements, including maintenance of appropriate animal and human subject approvals and monitoring of all the established policies for the inclusion of women and underrepresented minorities. It will be the liaison between the SPORE and the NCI- designated Jonsson Comprehensive Cancer Center, other UCLA academic and administrative bodies, NIH/NCI staff, IAB/EAB members, and patient advocacy groups. The Administrative Core will also ensure that data and resources are shared appropriately in order to promote intra- and inter-SPORE collaboration, provide integrated and centralized data management support through a new UCLA Brain SPORE Data Management (Brain-SPOD) platform, and maintain/update the UCLA Brain SPORE intranet and website. The Administrative Core is led by Linda M. Liau, MD, PhD, MDA, the SPORE principal investigator, who oversees all UCLA Brain Cancer SPORE activities.