# Project 3:  Strategies against radiation-induced cellular plasticity in glioblastoma

> **NIH NIH P50** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2022 · $370,368

## Abstract

PROJECT SUMMARY/ABSTRACT – Project 3
Despite decades of clinical trials, drug development, and technical advances in surgery and radiation oncology,
glioblastoma (GBM) remains incurable. While radiotherapy is still one of the most effective treatment options for
GBM, it cannot control the disease over time. This suggests that novel combination therapies are desperately
needed to improve radiation treatment outcome for patients suffering from this disease. The studies outlined in
this proposal are based on a hypothesis that is backed by our extensive preliminary data and published data.
The overall hypothesis is that targeting radiation-induced phenotype conversion of non-stem GBM cells into
radiation-resistant glioma-initiating cells using the dopamine receptor antagonist quetiapine (QTP) improves
radiation responses, generates an exploitable metabolic vulnerability, and can be safely applied in patients with
recurrent glioblastoma. The three aims of this study will address this hypothesis leveraging the unique resources
and expertise available within the UCLA SPORE in Brain Cancer. Aim 1 will study effect sizes and the duration
of changes in the mevalonate pathway in response to a novel combination therapy against GBM. Studies in Aim
2 will test the efficacy and safety of this combination therapy in patients with recurrent GBM. Finally, Aim 3 will
study the effect of this combination therapy on glioma initiating cells and explore the underlying mechanisms.

## Key facts

- **NIH application ID:** 10496441
- **Project number:** 2P50CA211015-06
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** Frank Pajonk
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $370,368
- **Award type:** 2
- **Project period:** 2017-08-11 → 2027-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10496441

## Citation

> US National Institutes of Health, RePORTER application 10496441, Project 3:  Strategies against radiation-induced cellular plasticity in glioblastoma (2P50CA211015-06). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10496441. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*