ABSTRACT: The Core A (Administrative Core) is led by the Program's PD/PI, Joe “Skip” G.N. Garcia MD, who will provide essential oversight of program and administrative operations to ensure overall direction and organization of the entire Program. Dr. Garcia and Core A members will be responsible for program direction and evaluation, program operations, and fiscal and scientific oversight. They will organize monthly PPG meetings, work with the PPG's Internal and External Scientific Review Panels and PPG Leaders, and coordinate PPG activities. The PPG Core A Program and Grant Administrator/Research Coordinator, reporting directly to Dr. Garcia, will handle day-to-day research details (research project coordination/oversight in addition to intra- and inter-institutional project utilization of the Cores and reagents exchange) and day-to-day administrative details (financial and administrative operations). In addition, this Core will provide accounting support that will ensure appropriate fiscal and scientific oversight, monitoring and compliance with federal and institutional grant management regulations, the latter through several formal mechanisms. The objectives of the Administrative core are: (i) to centralize all administrative actions and financial recording keeping; (ii) to prepare scientific and financial reports as required by the university and the NHLBI; (iii) to ensure that the PPG research meets the highest standards through periodic review by the internal and external review panels; (iv) to facilitate the use of common resources; (v) to provide the projects and cores with a review of all expenditures on a monthly basis as well as dealing with University Accounting and Grants offices concerning grant budgets; (vi) to provide the communication venues that foster exchange of scientific information and ideas and allow highly seamless communication between PPG scientists in Chicago and Tucson; (vii) to coordinate the regular virtual or in-person retreats between UA and UIC investigators for quarterly meetings, in Tucson and/or Chicago, in addition to the annual ATS conference. As this communication is vital to the success of the program, Core A personnel, will orchestrate the video conferencing of the: i) weekly meetings of individual Project and Core teams, ii) biweekly meetings of the Program Committee (led by Core A Leader and PPG PD/PI) where Project and Core leaders discuss scientific and administrative matters, and iii) regular monthly research seminars that will allow PPG investigators to present their work in progress to other researchers. In this A1 PPG renewal application, Core A will facilitate workflow between Chicago and Tucson, especially with regard to Core B, C, and D experiments and the critical exchange of reagents between Projects. Finally, Core A will coordinate the inter-project, inter-departmental, and inter- institutional collaborative arrangements and evolve new arrangements as deemed necessary for the scientific prog...