# PHASE I SBIR CONTRACT - TOPIC 415 - A Compact and Retrofittable Electronic Brachytherapy Source for Cancer Radiotherapy

> **NIH NIH N43** · EUCLID BEAMLABS, LLC · 2021 · $399,885

## Abstract

The use of electronic brachytherapy (EB) has grown rapidly over the past decade, and is gaining significant
interest from the global medical community as an improved user-friendly technology. However, the present EB machines
all use electron beams at energies of 100 kV or less to generate the X-ray photons, which limits their use to low dose-rate
brachytherapy. In this proposal, Euclid Beamlabs focuses on the development of an ultra-compact and light weight 1-
MeV electron source to generate and deliver >250 kV X-ray photons to the patient. The device is intended to retrofit to
existing brachytherapy applicators. Our proposed accelerating structure is a dielectric-based accelerator. Because of the
use of high permittivity dielectrics, the transverse size of the cavity is significantly reduced, becoming comparable to the
thickness of a pencil. With the help of optimized focusing elements, the beam will be transported through a 1~2-mm
diameter pipe to the Bremsstrahlung radiation target, thus delivering the dose in a highly localized regime. The
dimension of the pipe will be chosen for compatibility with existing brachytherapy applicators. In Phase I, we will develop
a fully functioning prototype and measure its critical parameters, including the delivered electron and photon energies,
the dose rate, etc. The Technical Readiness Level (TRL) of the developed technology will reach TRL4 (feasibility proved)
upon the completion of Phase I.

## Key facts

- **NIH application ID:** 10496695
- **Project number:** 75N91021C00054-0-9999-1
- **Recipient organization:** EUCLID BEAMLABS, LLC
- **Principal Investigator:** CHUNGUANG JING
- **Activity code:** N43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $399,885
- **Award type:** —
- **Project period:** 2021-09-16 → 2022-06-15

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10496695

## Citation

> US National Institutes of Health, RePORTER application 10496695, PHASE I SBIR CONTRACT - TOPIC 415 - A Compact and Retrofittable Electronic Brachytherapy Source for Cancer Radiotherapy (75N91021C00054-0-9999-1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10496695. Licensed CC0.

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