ABSTRACT Adverse Childhood Experiences (ACEs) have been identified as one of the strongest predictors of physical and mental health outcomes in children and adults and establish a trajectory of physical and mental health across the lifespan. Understanding the mechanisms/processes of adversity and resilience and how ACEs impact developmental trajectories will aid researchers and practitioners in targeting specific social and biological factors for intervention, prevention, treatment, and recovery. Leveraging the science of adversity and resilience will also impact public health approaches, including programs and policies, as well as awareness, prevention, and harm-reduction efforts aimed at reducing ACEs and promoting healing and recovery from ACEs . The Recruitment, Engagement, Collection, and Analysis (RECA) Core is a coordinated team of interdisciplinary researchers with a shared goal of furthering the science of adversity and resilience by supporting CoBRE Research Project Leads (RPLs) and Pilot Project Leads (PPLs) as they collect and analyze data that is multi- method, cutting-edge, and integrated data across Cores and disciplines. Integrated team science approaches are needed to further scientific understanding of the mechanisms and processes underlying the relationship between adverse childhood experiences (ACEs) and protective and compensatory experiences (PACEs) and outcomes and trajectories. Each project lead will be supported by the RECA Core with training and oversight of recruitment and retention, data collection, and analyses, in collaboration with the Biological Systems and Administrative Cores. Importantly, we will build a research databank across projects that includes common assessments of socio-emotional, neurocognitive, physical and mental health functioning, and environmental/contextual influences on health and related outcomes and will be available for approved investigators with and outside of the CoBRE. This databank is innovative because it combines data across multiple domains of biobehavioral functioning affected by adverse and protective childhood experiences in an area of the country where ACEs are high. These efforts are significant as they will yield transdisciplinary products to support a sustainable research center and a collaborative cadre of investigators and community partners focused on preventing ACEs and promoting resilience, resulting in improved health and mental health outcomes locally and beyond. 1