Modified Project Summary/Abstract Section While preventive care guidance recommends primary care clinicians deliver reproductive health (RH) care to male adolescents, males’ RH care receipt is poor. Clinic-based interventions can be valuable RH promotion tools for adolescents. Yet, they have mainly focused on RH care for girls or single topics rather than the recommended RH care package for males. Computer based approaches make it easier to consistently provide evidence-based RH education, in multiple languages, tailored to individual needs. Using such approaches before the clinic visit can also make it easier for clinicians’ work flow, such as time constraints and discomfort in discussing RH. Yet, we are not aware of any computer-based strategies for use in the clinical setting to promote recommended RH care for male adolescents. Neglecting to provide males with evidence-based RH care fails to meet their own needs, and compromises their partners’ health. Health-E You/Salud iTu is a pre-visit, individually tailored, interactive, web-based mobile intervention shown to improve hormonal contraceptive knowledge, self-efficacy, and use six months later. It also primes and extends clinicians’ ability to deliver individually tailored care to patients. The proposed study will adapt the current Health-E You for male adolescents to assess their RH needs; provide interactive, individually tailored, evidence-based RH information; support and prepare males’ RH decision-making and visit priorities; and support clinicians’ ability to individually tailor recommended care. We will then evaluate its acceptability, usability, satisfaction, and efficacy on RH care receipt and method use among male adolescents presenting for care at primary care settings. In this R01 proposal, we propose to (1) adapt Health- E You for use with male adolescents using an iterative Youth-Centered Health Design Process (YCHD) with males and input from an advisory board of male adolescents and clinicians; (2) ensure perceived acceptability, usability, and satisfaction of the final Health-E You app among male adolescent patients and clinicians using a YCHD approach; and (3) test its efficacy to improve sexually active male adolescent patients’ knowledge, self-efficacy, and behaviors related to RH care after the visit and method use 2 months later. The current proposal would be the first to examine the acceptability, usability, satisfaction, and efficacy of a pre-visit, computer-based intervention to engage male adolescent patients in RH care and method use, where currently no such strategy exists.