PROJECT SUMMARY The design and development of new experimental equipment, from electrophysiology to imaging to other prototyping, is critical for progress in vision research. This core will provide custom design and manufacturing for devices to interface new research technologies with their particular experimental preparations, to enhance collaborative sharing of device solutions, and thus to leverage new experimental techniques and speed progress in vision research. This core will provide the primary source of critical device, design and development of custom experimental equipment to NEl-funded vision research in the laboratories of numerous investigators, and serve as a centralized resource to promote shared device designs to facilitate entry into vision research and collaboration. The machine shop, which is housed within the Fairchild Building, will serve as one key node for providing this service. The machine shop will provide not only frequent services to construct innovative new equipment used in specific approaches in vision research, but will also be called upon to provide device design and development. In addition, the Core will facilitate design of specialized equipment to be fabricated via Stanford and, where indicated, outside 3-D printing services. Computer assisted design (CAD) programming and expert staff will be leveraged towards device development goals. The Core Director and Assistant Director have extensive experience with device development and the management of these resources. An explicit aim of this Core is to foster and facilitate collaboration and rapid sharing of progress among investigators by prioritizing innovative and collaborative vision research projects and communicating access and activity to all.