The Karnofsky score (1948) and the Eastern Cooperative Group ECOG PS (1982) are the standard for patient PS assessment and used as a key determinant for entry into a clinical trial and the initiation or continuation of any interventional therapy. Cansera has demonstrated using image analysis of footage from RGB-D cameras to quantify PS as a predictive biomarker in cancer care. RGB-D cameras captured patients performing a physical task in a clinic and patient movement is analyzed to predict PS. The phase I SBIR proposal will address the following technical challenges: 1) creating a reproducible method for data acquisition and extraction from RGB-D cameras; 2) developing a strategy for anonymizing RGB-D image dataset for an open access library; and 3) establishing requirements and designing for different user groups. The successful completion of the project will enable commercial application for a reproducible anonymized method for data acquisition and image capture using a RGB-D camera to objectively measure human performance providing a quantitative solution.