Abstract: The current standard-of-care for measurement of BP monitoring is the periodic use of occlusive arm- cuff devices. However, its utility is compromised by two critical limitations to measuring an individual’s true BP: 1) overall measurement inaccuracy and 2) inability to measure BP continuously. These limitations underscore a critical unmet need for accurate, continuous, non-invasive blood pressure (cNIBP) monitoring that can be used for management of hypertension (HTN) and other chronic diseases. To address this need, we have developed ViTrack™, a cuffless, wrist-wearable device that uses a fundamentally new method to accurately and non- invasively measure BP continuously. ViTrack’s beat-to-beat continuous measurements accurately provides patient’s true BP, including daytime and nighttime BP, circadian BP patterns, and BP variability (BPV). ViTrack also measures heart rate, respiratory rate, and wrist actigraphy to assess activity/sleep patterns. In Direct-to- Phase-II study [Grant#:1R44 HL158374-01] we are assessing BP parameters in a wide range of patients. ViTrack will address the need for accurate and continuous BP monitoring to prevent disabilities in persons with Alzheimer’s disease and its related dementias: HTN is the most common co-morbidity in persons with Alzheimer’s disease and its related dementias [1]. Effective HTN therapy offers the chance to reducing disability from cardiovascular or cerebrovascular events [2]. However, optimal management of HTN in people with dementia is hampered by the current dependence on periodic blood BP monitoring using occlusive arm-cuff devices [2]. Persons with dementia often have sleep disturbances and behavioral issues, in addition to autonomic dysfunction, which can significantly affect BP hemodynamics. These are almost never detected by random solitary measurements in the clinical setting [3,4,5]. Adding another challenge, dementia patients with poorer cognitive ability and behavioral issues do not tolerate frequent BP measurements [6]. HTN drug treatment tailored to circadian BP profile is critical to avoid orthostatic hypotension and/or hypotension, which can lead to weakness, contribute to falls and further cognitive decline [7,8,9,10]. Furthermore, the co-occurrence of behavioral events and BP changes in people with dementia is well recognized and perhaps modifications in BP could prevent or temper their agitation or aggression [11]. Thus, the development of rational therapeutic strategies to modulate BP and reduce disability in those with Alzheimer’s disease and its related dementias is dependent upon accurately assessing and characterizing their BP profile. ViTrack enables nonintrusive gathering of a patient’s beat-to-beat 24-h BP profile, both accurately and reliably, for the first time. ViTrack can address the need for accurate, continuous, and ubiquitous BP measurements for Alzheimer’s disease and vascular cognitive impairment–dementia prevention: Almost 40% of the US adult populat...