# The Role of ERBB4 in Atrial Electrophysiology and Atrial Fibrillation

> **NIH NIH R01** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2022 · $423,750

## Abstract

PROJECT SUMMARY
Atrial fibrillation (AF) is the leading cause of stroke and a major cause of morbidity and mortality in the US. AF is
due to both inherited and acquired factors. Genome-wide association studies have identified ERBB4 as a
candidate susceptibility gene for AF. Acquired conditions, such as aging, hypertension, and heart failure, are
known to cause electrical and structural changes in the left atrium (LA) in a process known as remodeling that
predisposes to AF. Our data show that left atrial ERBB4 levels are reduced in patients with AF. We have also
shown that ErbB4 is downregulated in heart disease mouse models. To study the role of ErbB4 in both atrial
electrical development and in acquired AF mechanisms, we have generated mouse models that have reduced
ErbB4 expression during development or acquired during adulthood. Both model systems show an important
dependency of correct ErbB4 gene dosage in the maintenance of normal atrial electrophysiology.

## Key facts

- **NIH application ID:** 10503131
- **Project number:** 1R01HL165130-01
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** David S Park
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $423,750
- **Award type:** 1
- **Project period:** 2022-08-01 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10503131

## Citation

> US National Institutes of Health, RePORTER application 10503131, The Role of ERBB4 in Atrial Electrophysiology and Atrial Fibrillation (1R01HL165130-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10503131. Licensed CC0.

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