# Genetically Informed Studies of Social Connectedness and Health

> **NIH NIH R01** · UNIVERSITY OF ARIZONA · 2022 · $918,251

## Abstract

7. PROJECT SUMMARY
A large body of evidence indicates that high-quality social relationships are correlated with decreased risk for
morbidity and mortality from a range of disease outcomes, and that social disconnection and poor relationship
quality are correlated with considerable risk for negative health outcomes. Although most of the work in this
area is correlational in nature, it is often interpreted as if it is causal. Genetically informed research methods
can allow researchers to rule-out causal explanations for epidemiological associations and/or identify effects
that may be consistent with a causal influence. Using co-twin control methods and a comprehensive new data
collection in the Washington State Twin Registry (WSTR), this grant brings together a diverse and established
scientific team to examine a series of unanswered questions around social relationships, health, and cognitive
functioning, all of which center on causal inference. The work in this proposal is guided by three Specific Aims
that will: (1) Conduct a detailed assessment of social relationship functioning in the WSTR and use
these variables in co-twin analyses of health and health behaviors. We will conduct a new data collection
on 1,000 adult twin pairs (N = 2,000) in the WSTR and complete a “deep phenotyping” of key relationship
quality variables, including social integration, relationship satisfaction/quality, and attachment styles. Under
Aim 1, we will also collect DNA methylation data and use a series of epigenetic clocks to characterize
accelerated biological aging among our main study outcomes; (2) Conduct a detailed neuropsychological
assessment of cognitive functioning in the WSTR cohort and use these variables as key outcomes in
co-twin models. Social isolation and loneliness may hasten declines in cognitive functioning, but are these
associations consistent with a causal effect? We will conduct detailed neuropsychological assessments of the
2,000 WSTR participants using assessments that target cognitive outcomes shown to be associated with
accelerated cognitive decline, mild cognitive impairment, and biomarkers of Alzheimer’s disease and related
dementias; and (3) Examine the association between objective measures of daily social functioning and
the health and cognitive outcomes in the WSTR. The Electronically Activated Recorder (EAR) is a
smartphone application that records ambient sounds in participants’ daily lives and provides a means of
assessing social behaviors beyond self-report alone. We will collect EAR data from a sub-sample of 140 adult
MZ twin pairs discordant for marital status (N = 280) from the WSTR to determine if within twin-pair differences
in the objective indices of social integration are associated with the health, health behavior, and cognitive
outcomes. Successful completion of the proposed research will help build a causal foundation for public health
intervention efforts around social relationships.

## Key facts

- **NIH application ID:** 10503656
- **Project number:** 1R01AG078361-01
- **Recipient organization:** UNIVERSITY OF ARIZONA
- **Principal Investigator:** DAVID A SBARRA
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $918,251
- **Award type:** 1
- **Project period:** 2022-08-15 → 2027-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10503656

## Citation

> US National Institutes of Health, RePORTER application 10503656, Genetically Informed Studies of Social Connectedness and Health (1R01AG078361-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10503656. Licensed CC0.

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