# Northern New England Clinical and Translational Research Network

> **NIH NIH U54** · MAINEHEALTH · 2022 · $4,299,999

## Abstract

The long-term goal of the Northern New England Clinical and Translational Research Network (NNE-CTR),
composed of MaineHealth, the University of Vermont, and the University of Southern Maine, is to sustain a
clinical and translational research infrastructure that supports improvements in community health for northern
New England inhabitants. Maine and Vermont have the oldest populations in the U.S. and that, coupled with
rurality, predisposes residents to a range of disorders ranging from cancer to substance use disorders, food
insecurity, obesity, diabetes and cardiovascular disease. In addition, northern New England has a growing
underserved immigrant population, as well as a Native American population. Our communities have been
challenged by the Covid-19 pandemic, and we are addressing these challenges by linking primary care
practice centers with academic centers and developing innovative approaches to community-based research.
During our first four years, the NNE-CTR has built a strong foundation for clinical research. We partnered with
the oldest regional practice-based research network (PBRN), the Dartmouth Co-Op, and actively supported
successful NIH program applications, including two COBREs, two NCI program grants, an infrastructure grant
for a new Center for Biomedical Shared Resources, and a HRSA grant to build on the opioid treatment model
pioneered in Vermont. The NNE-CTR PI is playing a leadership role in coordinating a national CTR network,
including the CTR National COVID Cohort Collaborative (N3C), a registry to share clinical data on Covid-19
nationally, and the NIH-sponsored RECOVER trial, which will define the long-term sequelae of Covid-19. In
this renewal, we plan to expand our collaborations both regionally and nationally, strengthen our PBRN, and
embrace cultural diversity. We will strengthen Core resources that include: the Biostatistics, Epidemiology and
Research Design Core, which will improve data capability and research navigation services; the Professional
Development Core, which will offer an array of new educational and mentorship opportunities; the Pilot
Projects Program, which will provide new and flexible funding mechanisms to offer more support for
community-based projects; the Translational Research and Technology Core, offering state-of-the-art
technologies and training for new investigators, and the Community Engagement and Outreach Core, which
will build stronger bridges to underserved communities. We propose three specific aims: 1-Expand
infrastructure and resources to address clinical and translational research needs in northern New England; 2-
Strengthen clinical and translational research that addresses health equity and disparities encountered by at-
risk populations, including expansion of clinical trial access, telehealth, and mentored training programs for
new investigators; and 3-Accelerate regional and national collaborative initiatives within the IDeA networks
and through NIH such as N3C and REC...

## Key facts

- **NIH application ID:** 10505149
- **Project number:** 2U54GM115516-06
- **Recipient organization:** MAINEHEALTH
- **Principal Investigator:** CLIFFORD JAMES ROSEN
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $4,299,999
- **Award type:** 2
- **Project period:** 2017-07-03 → 2027-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10505149

## Citation

> US National Institutes of Health, RePORTER application 10505149, Northern New England Clinical and Translational Research Network (2U54GM115516-06). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10505149. Licensed CC0.

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