PROJECT SUMMARY NCRAD plays a key leadership role in study protocol development and site training. NCRAD utilizes standardized approaches to sample banking, storage, and retrieval. Over the past decade, DNA banking at NCRAD has become a standard practice for all ADRCs. NCRAD now maintains DNA from 29,424 ADRC-evaluated research participants with a uniform dataset (UDS) and another 3,823 with the previously developed minimal dataset. Full longitudinal clinical data for these samples are housed at the NACC with a limited data set of key variables transferred to NCRAD. NCRAD is now broadening the range of blood-based samples banked from the well characterized ADRC participants. With the rapid development of blood-based biomarkers, there is an urgency to have a central laboratory in the United States that can process large numbers of samples in a standardized manner. NACC and NCRAD will collaborate on collecting the blood sample data and providing incentive payments to the ADRCs via modifying the existing subaward agreements at NACC as well as build more efficient data systems to store large data to be easily accessible by the data group and admin team at NACC.