# THE PURPOSE OF THIS MODIFICATION IS TO CREATE ISOGENIC CELL CONTROL LINES FOR THE LINES CURRENTLY BEING CREATED.

> **NIH NIH N01** · NEW YORK STEM CELL FOUNDATION · 2021 · $149,500

## Abstract

The New York Stem Cell Foundation (NYSCF) Research Institute and the NIH National Eye Institute (NEI) have generated induced Pluripotent Stem Cells (iPSCs) from age-related
macular degeneration (AMD) patients, which are available for distribution to the vision research community. The patients are enrolled in the Age-Related
Eye Disease Study (AREDS) and were selected by NEI. The initial lines have mutations in genes that are known to confer high risk towards developing
AMD. The AREDS iPSC cohort will have its extensive clinical and medical data available to researchers and the hope is that phenotypic correlations with
these lines will spur a better understanding of how AMD starts and progresses. PBMCs were isolated from whole blood, reprogrammed to iPSCs via
Sendai virus, monoclonalized, expanded, and QC assays performed using the NYSCF Global Stem Cell Array®. iPSCs will be distributed with an SOP for
thawing and expansion and a Certificate of Analysis (CoA).

## Key facts

- **NIH application ID:** 10506171
- **Project number:** 263201800007C-P00004-9999-1
- **Recipient organization:** NEW YORK STEM CELL FOUNDATION
- **Principal Investigator:** SCOTT NOGGLE
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $149,500
- **Award type:** —
- **Project period:** 2018-09-25 → 2022-03-24

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10506171

## Citation

> US National Institutes of Health, RePORTER application 10506171, THE PURPOSE OF THIS MODIFICATION IS TO CREATE ISOGENIC CELL CONTROL LINES FOR THE LINES CURRENTLY BEING CREATED. (263201800007C-P00004-9999-1). Retrieved via AI Analytics 2026-06-10 from https://api.ai-analytics.org/grant/nih/10506171. Licensed CC0.

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