Administrative Core Abstract The PCHPI will establish an Administrative Core comprising the program co-directors, an executive committee, a scientific advisory board, a PhD-level communications coordinator, financial administrators, and IT personnel. The Administrative Core will be responsible for overseeing the center operations as a whole and for ensuring progress toward our overall goals, considering the NIAID mission and the current state of HIV-1 structural biology, as reported in the literature and through scientific symposia. Specifically, the Administrative Core will i) establish and implement a robust management and intra-center communications plan; ii) draft, update and implement strategic plans; iii) establish a versatile infrastructure and effective mechanisms for launching and maintaining collaborations; iv) coordinate inter-center and extra-center communications and activities; and v) ensure timely deposition of data in appropriate databases and repositories and facilitate data and resource sharing with the community.