# The biophysics and potential cell-type selectivity of acoustic neuromodulation

> **NIH NIH R01** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2022 · $352,409

## Abstract

Summary
 Neuroscience has an essential requirement for large-scale perturbation tools. Such tools
would be transformative in the mapping of brain function and the diagnosis and treatment of
neurological disorders. The proposed project is aimed at uncovering a potential therapeutic role
for US neuromodulation (USNM) in Alzheimer’s disease, following up on early phenomenological
observations that focused US may have such an impact.
 Our project’s goal is to use state-of-the-art in vivo imaging techniques to understand how
US could be used to study and manipulate cerebrospinal fluid (CSF) flow in the brain, with
applications focused on Alzheimer’s disease, using combined US and simultaneous fluorescence
microscopy of amyloid-β and tau. We will study if USNM effects in the brain can lead to changes
in blood and CSF flow, and whether USNM induced flow effect amyloid-β or tau clearance in the
brain.

## Key facts

- **NIH application ID:** 10509833
- **Project number:** 3R01NS109885-04S2
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** Robert Crooks Froemke
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $352,409
- **Award type:** 3
- **Project period:** 2022-04-01 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10509833

## Citation

> US National Institutes of Health, RePORTER application 10509833, The biophysics and potential cell-type selectivity of acoustic neuromodulation (3R01NS109885-04S2). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10509833. Licensed CC0.

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