# Suppression of Prostate Cancer

> **NIH NIH R21** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2022 · $236,050

## Abstract

Project Summary
As many as 20% of aggressive prostate cancers have mutations resulting in upregulation of Wnt/β-catenin
signaling. Importantly, recent analysis identified the Wnt/β-catenin pathway as the foremost differentially
modulated pathway among treatment-resistant individuals. We used structure-based design of peptidomimetic
oligomers to discover new molecules capable of inhibiting Wnt/β-catenin signaling and prostate cancer cell
growth. We identified macrocycle 13 as a potent inhibitor of Wnt/β-catenin signaling. In this proposal we outline
a strategy to use macrocycle 13 in models of castration resistant prostate cancer (CPRC) and to explore the
biology of Wnt/β-catenin in prostate cancer. The hypothesis underlying of this project is that oligomer
macrocycles can be rationally designed to inhibit the β-catenin/TCF interaction, thereby inhibiting prostate
cancer tumor growth. Our specific aims are to 1) test macrocycle 13 inhibition of -catenin/TCF in in vivo
models of aggressive prostate cancer and 2) determine macrocycle 13/β-catenin binding characteristics.
Altogether, we expect that completion of our research goals will provide new molecular insight into Wnt/β-
catenin signaling in prostate cancer.

## Key facts

- **NIH application ID:** 10512253
- **Project number:** 1R21CA262963-01A1
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** Susan K. Logan
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $236,050
- **Award type:** 1
- **Project period:** 2022-09-01 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10512253

## Citation

> US National Institutes of Health, RePORTER application 10512253, Suppression of Prostate Cancer (1R21CA262963-01A1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10512253. Licensed CC0.

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