# CORE 1 - Animal Phenotyping Core

> **NIH NIH P30** · UT SOUTHWESTERN MEDICAL CENTER · 2022 · $164,000

## Abstract

PROJECT SUMMARY/ABSTRACT – Core 1 – Animal Phenotyping/Metabolism Core
The services provided in the Animal Phenotyping/Metabolism Core draw upon the expertise of many
investigators at UTSW to provide comprehensive analytical capabilities that are on par with the best facilities in
the world. We established our Animal Phenotyping/Metabolism Core more than 12 years ago and we have
continued to expand our assay capabilities to support investigators with in-depth preclinical capabilities.
The availability of standardized assays speeds the pace of our research, facilitates inter-lab comparisons of data,
and provides a common platform for the necessary close interactions between investigators of the NORC.
Animal models that allow careful characterization of the metabolic effects of obesity and that have an altered
communication axis between critical tissues and are vital to understand the pathogenesis of disease. Given the
number of phenotypic measurements, the range of target metabolites, and the number of different animal models
investigated among the NORC investigators, it is necessary to provide uniform measurements and to have
quality control guidelines in place. To facilitate the research of NORC investigators, Core 1 will provide
comprehensive, state-of-the-art measurements of multiple metabolic parameters, with measurements
involving physiological read outs that include lipid, glucose, and metabokine assays.
The technical expertise offered by the Animal Phenotyping/Metabolism Core will bring multiple benefits to NORC
investigators, including but not limited to the following:
 Centralized Core services that are more cost effective and prevent the duplication of reagents across
 NORC investigators.
 Provides consistency in various assays across laboratories.
 Provides consistent quality control measures.
 Makes available technically challenging assays, such as hyperinsulinemic-euglycemic clamps, that
 cannot be established in individual laboratories.
 Makes available equipment that is essential for nutrition and obesity research but that is too expensive
 for individual investigators to purchase (e.g. Seahorse, MRI, metabolic cages, animal CT).
 Frees investigators from routine work to focus on the intellectual challenges of the projects.

## Key facts

- **NIH application ID:** 10512733
- **Project number:** 1P30DK127984-01A1
- **Recipient organization:** UT SOUTHWESTERN MEDICAL CENTER
- **Principal Investigator:** PHILIPP E SCHERER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $164,000
- **Award type:** 1
- **Project period:** 2022-07-01 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10512733

## Citation

> US National Institutes of Health, RePORTER application 10512733, CORE 1 - Animal Phenotyping Core (1P30DK127984-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10512733. Licensed CC0.

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