Project Summary: Cyberinfrastructure Enhancement Core The vision for the Cyberinfrastructure Enhancement (CE) Core is to strengthen the partner network, scale clinical accomplishments made in overcoming health disparities during COVID-19 and create a sustainable growth model for clinical and translational infrastructure and workforce development in our state. To accomplish this vision, we will provide, update, and maintain “state of the art” computing and informatics resources; further developing the infrastructure to support the clinical and translational research projects of LA CaTS investigators with the goal of reducing Louisiana's chronic disease burden. We will accomplish our goals by pursuing the following specific aims. Aim 1. To facilitate clinical and translational research administration and data management using secure and proven cyberinfrastructure resources and tools, providing investigators a common ground through which to conduct research. We will accommodate hybrid working scenarios brought about by the COVID pandemic, by adapting such a toolset to be as effective remotely, as it is from the researcher's clinic or office. Aim 2. Provide resilient video conferencing resources to support telehealth, educational, and community engagement efforts across the state which will enhance communication during the COVID-19 pandemic and beyond. CE will leverage the high-speed networks of Louisiana Optical Network Infrastructure (LONI) and a palette of proven technologies to support investigators and communities with known health disparities and poor access to information and care. Aim 3. To leverage existing web-based tools for disseminating general information and for enhancing communication among all LA CaTS cores. CE will provide and support an advanced central coordination point for both internal and external communication that will serve as the primary repository of information about the LA CaTS Center for technical and lay audiences alike. The completion of these aims will significantly enhance and support investigators in their goal to improve health outcomes and address disparities in Louisiana by providing a wealth of computing resources that will greatly facilitate their research. Tighter collaboration with all cores will yield a more tailored approach highlighted by adoption, extension, and customization of available applications as well as the required infrastructure to provide scalable and reliable cyber solutions for all LA CaTS investigators.