# Core B – Medicinal and Process Chemistry

> **NIH NIH U19** · EMORY UNIVERSITY · 2022 · $10,548,554

## Abstract

Project Summary – Core B
The Medicinal Chemistry Core (Core B) of the Antiviral Countermeasures Development Center (AC/DC) will be
composed of the combined capacity of the Emory Institute for Drug Development (EIDD) and the research group
of Professor Dennis Liotta. This Core will centralize all AC/DC chemistry operations including medicinal
chemistry, scale-up synthesis, process development and preformulation profiling into a highly efficient team that
will reduce redundant research around chemotypes that are of interest to multiple Projects. It will also interact
closely with all AC/DC Projects and Cores to allow for an unprecedented level of synergy and integration
throughout the Center. The AC/DC will have a compelling set of leads, early leads and validated hits in its pipeline
at various stages of development and optimization at the onset of operations. These compounds present a wide
array of chemotypes that will be pursued in parallel, including broadly active ribonucleoside leads, non-
nucleoside viral polymerase inhibitor leads, and viral protease inhibitor hits. New validated hits emerging from
Core F (HTS) will also be advanced through iterative SAR optimization to ensure an ongoing robust pipeline of
drug candidates at various stages of development. Finally, Core B will develop scale-up processes and
preformulation profiles to support the advancement of late leads throughout the AC/DC.

## Key facts

- **NIH application ID:** 10513937
- **Project number:** 1U19AI171403-01
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Michael George Natchus
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $10,548,554
- **Award type:** 1
- **Project period:** 2022-05-16 → 2026-10-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10513937

## Citation

> US National Institutes of Health, RePORTER application 10513937, Core B – Medicinal and Process Chemistry (1U19AI171403-01). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/10513937. Licensed CC0.

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