# Pandemic Assistance Core

> **NIH NIH U19** · STANFORD UNIVERSITY · 2022 · $5,598,964

## Abstract

PROJECT SUMMARY/ABSTRACT
The Pandemic Assistance Core will enable investigators in this AViDD center to rapidly develop antiviral
therapeutics for SARS-CoV-2 and other RNA viruses of pandemic potential. This core will provide capacity for
rigorous in vitro and in vivo testing of compounds developed across all seven Projects, with a particular
emphasis on providing unparalleled BSL3 and ABSL3 capacity. We will quickly and efficiently refine our targets
and down-select from a series of go/no-go decisions over the course of our project, providing a funnelling
structure to rapidly identify the most promising candidates both in vitro and in vivo. Compounds will be tested in
both prophylactic and therapeutic models. As our Projects take unique approaches to target the viral life cycle,
lead candidates from each project will also be tested in combination to identify synergism. The most promising
of the lead candidates will then be sent for further development within the Translation Accelerator Core. To
achieve this work we have brought together an outstanding and interdisciplinary team of investigators with
significant experience in virology, drug development, and rodent models for drug screening. We also bring
highly innovative approaches to test compounds in physiologic systems using human air-liquid interface (ALI)
models and human adult lung organoids (ALO). We aim to provide industry-level capacity for screening and
selecting the most promising drug candidates.

## Key facts

- **NIH application ID:** 10514267
- **Project number:** 1U19AI171421-01
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Catherine A Blish
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $5,598,964
- **Award type:** 1
- **Project period:** 2022-05-16 → 2026-10-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10514267

## Citation

> US National Institutes of Health, RePORTER application 10514267, Pandemic Assistance Core (1U19AI171421-01). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10514267. Licensed CC0.

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