# Translation Accelerator Core

> **NIH NIH U19** · STANFORD UNIVERSITY · 2022 · $14,783,804

## Abstract

ABSTRACT: The goal of the Translation Accelerator Core is to provide the appropriate expertise and
resources to advance the translational efforts of the Stanford AViDD Center projects with industry-level rigor.
Embedded in the Core is an Industry Consultants Consortium that will provide expert support for all key facets
of successful preclinical development—from lead identification, to lead optimization, to nomination of a
development candidate, and appropriate IND-enabling studies. This preclinical development includes virtual
small molecule screening, computational chemistry and modeling, medicinal chemistry, in vitro characterization
of drug metabolism and pharmacokinetic (DMPK) properties, formulation, scale-up and process chemistry
including analytical methods development, in vivo toxicology and characterization of drug metabolism and
pharmacokinetic (DMPK) properties, and regulatory affairs. Finally, to ensure these efforts are efficient and
maximally productive, we have assembled a trio of world-class directors of research from industry, and
incorporated organizations and industry partners whose mission and resources are dedicated to helping
compelling lead molecules advance towards commercialization. Successful accomplishment of this Core’s
efforts will enable the development of new classes of outpatient antiviral therapeutics for SARS-CoV-2 and
other RNA viruses of pandemic potential.

## Key facts

- **NIH application ID:** 10514268
- **Project number:** 1U19AI171421-01
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Kevin V Grimes
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $14,783,804
- **Award type:** 1
- **Project period:** 2022-05-16 → 2026-10-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10514268

## Citation

> US National Institutes of Health, RePORTER application 10514268, Translation Accelerator Core (1U19AI171421-01). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10514268. Licensed CC0.

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