# Animal and Organoid Model Core

> **NIH NIH U19** · SCRIPPS RESEARCH INSTITUTE, THE · 2022 · $1,131,670

## Abstract

SUMMARY
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2), exploded into a global pandemic in late 2019 causing significant loss of life, pronounced economic
disruption and major long-term medical impacts which are still being characterized. The current COVID19
pandemic highlighted our severe lack of preparedness and, despite an effective vaccine being developed in
record time, the continued need for efficacious antiviral drugs to quell the morbidity and mortality associated with
infection became evident. Despite an accelerated push to identify and bring forward anti-viral medicines, few
made it to the clinic in time to prevent the approximately 700,000 deaths observed in the United States and
several million across the globe. Moreover, many emerging and re-emerging viral diseases with pandemic
potential have been identified which could bring similar or excess morbidity and mortality as COVID19 in a future
pandemic event. This pandemic highlights the need to get ahead of viruses with pandemic potential to be ready
for the next outbreak. As such, the goal of this proposal is to identify novel, direct-acting antivirals.
 The broad, long-range objectives of the Animal and Organoid Model Core (Core D) are to develop/employ
organoid and animal models for testing of selected candidate anti-viral compounds generated in projects 1-6 of
this U19 application. The Animal and Organoid Model Core will work in conjunction with the project leaders
(projects 1-6), HTS core (Core A), medicinal chemistry core (Core B) and the absorption, distribution,
metabolism, excretion and toxicity (ADMET)/formulation core (Core C) to identify, modify and formulate
candidate hits for in vivo testing in the animal models. The primary goal will be the development of potent, orally
bioavailable direct acting antiviral compounds against specific Coronavirus, Flavivirus and Bunyavirus targets
described within this proposal.

## Key facts

- **NIH application ID:** 10514322
- **Project number:** 1U19AI171443-01
- **Recipient organization:** SCRIPPS RESEARCH INSTITUTE, THE
- **Principal Investigator:** John Ross Teijaro
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,131,670
- **Award type:** 1
- **Project period:** 2022-05-16 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10514322

## Citation

> US National Institutes of Health, RePORTER application 10514322, Animal and Organoid Model Core (1U19AI171443-01). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10514322. Licensed CC0.

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