# NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of Inflammation

> **NIH NIH R37** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2023 · $600,599

## Abstract

See Abstract page
RELEVANCE (See instructions):
We will continue to study the role of mitochondrial DNA metabolism in NLRP3 inflammasome activation
and the effect of NRF2 on macrophage polarization. We will examine whether the pathogenesis of
osteoarthritis (OA) and Alzheimer’s disease (AD) in mice is accompanied by oxidized mitochondrial DNA
generation, its cleavage and export to the cytosol. We will also test the ability of CMPK2 and Fen1
inhibitors to attenuate NLRP3 inflammasome activation in OA, AD and other disease models.

## Key facts

- **NIH application ID:** 10516935
- **Project number:** 4R37AI043477-26
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Michael Karin
- **Activity code:** R37 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $600,599
- **Award type:** 4C
- **Project period:** 2023-06-01 → 2028-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10516935

## Citation

> US National Institutes of Health, RePORTER application 10516935, NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of Inflammation (4R37AI043477-26). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10516935. Licensed CC0.

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