# Administrative Core

> **NIH NIH U54** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2022 · $143,951

## Abstract

ADMINISTRATIVE CORE – SUMMARY
The proposed Acquired Resistance to Therapy and Iron (ARTI) Center is focused on the role of ferroptosis
in acquired resistance to radiation therapy. Radiation therapy is used to treat approximately 50% of cancer
patients and is standard of care treatment for lung cancer and esophageal cancer patients. The ARTI Center will
focus on these cancer types and comprise three research projects. Project 1 will focus on identifying the
mechanisms of ferroptosis in acquired resistance to radiation therapy and testing ferroptosis inducers (FINs) as
radiosensitizers. Project 2 will focus on determining whether hypoxia-induced resistance to ferroptosis
contributes to acquired tumor resistance to radiation therapy and whether FINs re-sensitize hypoxic tumor cells
to radiation treatment. Project 3 will focus on understanding the role of genomic and microenvironment factors
in acquired resistance to ferroptosis to chemoradiation in esophageal adenocarcinoma. The three research
projects will be supported by one shared Molecular Imaging Core (MIC), which will provide imaging tools and
analyses for measuring tumor growth, assessing the ability to overcome acquired radiation resistance using
combination therapies (e.g., FINs with radiation therapy or immunotherapy), identifying intratumoral hypoxic
regions, and evaluating myeloid cell expansion in conferring ferroptosis resistance to chemoradiation therapy.
To support the MIC and these three projects, the Administrative Core (AC) will be established as part of the
ARTI Center infrastructure that will support, coordinate, and facilitate all activities aimed at achieving and
evaluating milestones across the projects and core. The AC will establish and maintain engagement and
communication among ARTI Center and ARTNet members and program officials in Aim 1. In Aim 2, the AC will
facilitate ARTI Center evaluation, support the timely and quality development and submission of progress
reports, and maintain proper and transparent stewardship of funds. The AC will develop and implement an
internal solicitation and prioritization process for Pilot and Trans-Network Projects in Aim 3. In Aim 4, the AC
will serve as the central infrastructure to build a website and manage data, materials, resources, conflict
resolution, and issues of intellectual property for technologies and tools. The multiple Principal Investigators
(mPIs) of the ARTI Center, Boyi Gan, PhD and Albert Koong, MD, PhD, will serve as AC Co-Leaders. Under
their leadership, the AC will be able to leverage institutional and divisional resources; to establish and maintain
an ARTI Center Advisory Committee; to encourage the development of junior faculty, trainees, and students in
cancer research; to promote collaborations across ARTNet; and to ensure abidance by the ARTNet governance
and resource and data sharing policies. Overall, the AC will be the central juncture for the ARTI Center to
integrate with other ARTNet centers as well as ...

## Key facts

- **NIH application ID:** 10517141
- **Project number:** 1U54CA274220-01
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **Principal Investigator:** Boyi Gan
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $143,951
- **Award type:** 1
- **Project period:** 2022-09-20 → 2027-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10517141

## Citation

> US National Institutes of Health, RePORTER application 10517141, Administrative Core (1U54CA274220-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10517141. Licensed CC0.

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