# Dissecting the in vivo stromal metabolic and inflammatory crosstalk in colorectal cancer

> **NIH NIH R50** · WEILL MEDICAL COLL OF CORNELL UNIV · 2022 · $177,778

## Abstract

SUMMARY
This proposal seeks Dr. Angeles Duran’s salary support as a Research Specialist to support Dr. Jorge Moscat’s
research program at the Weill Cornell Medicine Department of Pathology and Laboratory Medicine to study the
role of the tumor microenvironment (TME) in colorectal cancer (CRC). Dissecting the role of these complex
cellular interactions requires scientists with an in-depth understanding of the biology of these processes, but also
with the required technical expertise in in vivo mouse models that faithfully recapitulate human disease, as well
as the necessary bioinformatics tools to interrogate the TME of these models at the single-cell level. Therefore,
with this Research Specialist Award, we intend to provide stable research opportunities for the exceptional
scientist, Angeles Duran, to develop impactful research in this area of expertise. She has made seminal
contributions in signaling, inflammation, metabolism and cancer and has a strong interdisciplinary training that
will be critical for the success of the project. She will contribute to the research program focused on defining the
molecular and cellular mechanisms that drives mesenchymal CRC, a desmoplastic and of poor prognosis type of
cancer. With her expertise in cancer biology and her capacity to apply novel mouse models and bioinformatics
approaches, she is filling a unique niche within the Moscat lab that will provide continuity, stability, and detailed
scientific knowledge to achieve the aims of the NCI-funded grants. She will support this project with scientifically
impactful in vivo models and bioinformatics approaches. Dr. Duran’s long-time expertise and dedication will
advance our understanding of the role of TME in cancer progression to help design more effective therapies.

## Key facts

- **NIH application ID:** 10517637
- **Project number:** 1R50CA265332-01A1
- **Recipient organization:** WEILL MEDICAL COLL OF CORNELL UNIV
- **Principal Investigator:** Maria Angeles Duran Molina
- **Activity code:** R50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $177,778
- **Award type:** 1
- **Project period:** 2022-08-16 → 2027-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10517637

## Citation

> US National Institutes of Health, RePORTER application 10517637, Dissecting the in vivo stromal metabolic and inflammatory crosstalk in colorectal cancer (1R50CA265332-01A1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10517637. Licensed CC0.

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