PROJECT SUMMARY/ABSTRACT: Administrative Core The overall goal of our leukemia focused ARTNet Research Center is to understand how the architecture of resistance is governed by temporal extrinsic and intrinsic factors in order to identify novel therapeutic strategies to stay ahead of tumor evolution and adaptation in patients with Acute Myeloid Leukemia (AML). To achieve this goal, we have assembled an exceptional team of leukemia researchers that bridge basic/mechanistic and preclinical/translational research who have worked extensively together for 15+ years studying AML biology. The Administrative Core will provide leadership, scientific oversight, governance, integration, and administrative support to the ARTNet Research Center to ensure effective operations, communication, internal and external collaborations, compliance, and rigorous scientific evaluation of ARTNet Consortium funded projects. The Administrative Core co-Leads, Dr. Jeffrey Tyner (Contact M-PD/PI) and Dr. Cristina Tognon, have been working together for close to a decade, and they have also both worked closely for this entire time with Administrative Core Biostatistics and Bioinformatics Lead and Overall M-PD/PI, Dr. Shannon McWeeney. They will be supported by a highly experienced Research and Finance Administrator, Sarah Bowden. The specific aims of the Administrative Core are to: 1) Provide overall administrative management by providing governance and scientific integration of the Center and developing and implementing a staffing plan; 2) Create an environment that fosters a focused and synergistic relationship between the Projects and the Cores; 3) Provide ARTNet Research Center compliance oversight and evaluate scientific progress; and 4) Enable rapid dissemination of data and resources. To achieve these aims, the Administrative Core will establish and implement ARTNet Research Center governance, including establishing a Scientific Advisory Board (SAB) to help evaluate the Center’s progress toward its aims and milestones; plan regular strategic interactions and meetings; develop communication plans; ensure budget oversight and compliance; manage intellectual property issues; complete annual progress reports; facilitate regular and timely communication; facilitate collaboration within the Center and with external collaborations; and perform all other administrative duties required to support the ARTNet Research Center and its successful participation in the Acquired Resistance to Therapy Network.