# Integration of immune cell subtypes across diseases & tissue

> **NIH NIH U01** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2022 · $405,000

## Abstract

Abstract
Single cell and single nucleus-based data have now been generated from many different tissues
in the AMP projects as well as blood, CSF, synovial fluid and other biosamples. We have
generated an atlas of microglial subtypes1 and are analyzing over 1.8 million transcriptomes
from individual nuclei collected from the frontal cortex of 436 participants.2 We have a portfolio
of additional single cell projects generating data from additional brain collections, peripheral
blood mononuclear cells from healthy subjects and multiple sclerosis (MS) patients, as well as
CSF cells from MS, other neuroinflammatory, and older individuals with and without Alzheimer.
There are also data from other local and external efforts related to the Human Cell Atlas and
related projects that can help to broaden the capture of immune cell states from a variety of
tissue environments, context of comorbidities and diverse subjects. However, these resources
have yet to be brought together to create a joint reference relating the different immune cell
subtypes and cell states together in a single framework to accelerate the translation of insights
across the AMP spectrum. Here, we integrate all of these and other emerging data to have a
shared framework with which to interpret the cellular composition of immune responses involved
in inflammatory, metabolic and neurologic diseases.

## Key facts

- **NIH application ID:** 10518099
- **Project number:** 3U01AG061356-04S1
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** DAVID ALAN BENNETT
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $405,000
- **Award type:** 3
- **Project period:** 2018-09-30 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10518099

## Citation

> US National Institutes of Health, RePORTER application 10518099, Integration of immune cell subtypes across diseases & tissue (3U01AG061356-04S1). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/10518099. Licensed CC0.

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