# Progenitor cell based therapy to mitigate radiation induced gastro intestinal syndrome- supplement

> **NIH NIH U01** · UNIVERSITY OF KANSAS MEDICAL CENTER · 2022 · $99,999

## Abstract

Project Summary:
Currently, there is a need for strategies that mitigate acute radiation-induced gastrointestinal syndrome (RIGS).
The risk of large populations including children encountering radiation exposure is real and growing. Although
some studies have been performed in development of MCM targeting adult population almost no information is
available for pediatric population. Unavailability of a suitable pediatric models further limits any progress on
development of MCM for children. The high radiosensitivity of the intestinal epithelium increases susceptibility
to RIGS; and with mortality within 10-15 days there is limited time for therapeutic intervention. We have
developed a human myeloid committed progenitor (MCP) cell therapy which can mitigate RIGS and improve
survival when applied 24 hr after an otherwise lethal dose of radiation exposure. These progenitor cells are
modulated ex-vivo to increase expression of WNT ligand, a major paracrine signal for intestinal epithelial
regeneration. In this project we will fully characterize RIGS using pediatric rodent model. Finally we will
evaluate the involvement of MCP derived WNT signaling in repair and regeneration of intestinal stem cells in
this model.

## Key facts

- **NIH application ID:** 10518204
- **Project number:** 3U01AI138323-05S1
- **Recipient organization:** UNIVERSITY OF KANSAS MEDICAL CENTER
- **Principal Investigator:** Subhrajit Saha
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $99,999
- **Award type:** 3
- **Project period:** 2018-03-07 → 2024-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10518204

## Citation

> US National Institutes of Health, RePORTER application 10518204, Progenitor cell based therapy to mitigate radiation induced gastro intestinal syndrome- supplement (3U01AI138323-05S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10518204. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*