# HIP fracture Accelerated surgical TreaTment And Care tracK-2 (HIP ATTACK-2) trial

> **NIH NIH U01** · UNIVERSITY OF MARYLAND BALTIMORE · 2022 · $1,004,029

## Abstract

ABSTRACT
The proposed trial, HIP ATTACK-2, seeks to improve the outcomes of thousands of patients who present to the
hospital with a hip fracture and concomitant acute heart injury. Acute heart injury is characterized by an elevated
serum troponin; this heart injury is often asymptomatic but can be identified in up to 20% of hip fracture patients
prior to surgery. These patients have a much worse prognosis than patients with no heart injury (i.e., 24% versus
8% 90-day mortality, respectively). Despite the magnitude of this problem, standard medical management has
made little progress in improving the outcomes of these patients. The objective of the HIP ATTACK-2 trial is to
confirm the previous post-hoc subgroup findings by comparing accelerated surgery (<6 hours) to standard care
in hip fracture patients presenting with elevated serum troponin. This multicenter, parallel group randomized
controlled trial will address three specific aims: 1) to determine if accelerated surgery reduces the risk of 90-day
mortality in hip fracture patients who also have an acute heart injury, 2) to determine if accelerated surgery
increases the proportion of patients able to independently ambulate 10 feet at 90-days, 3) to determine if
accelerated surgery improves patient-reported quality of life and decreases medical and surgical complications.

## Key facts

- **NIH application ID:** 10518429
- **Project number:** 1U01AR080377-01A1
- **Recipient organization:** UNIVERSITY OF MARYLAND BALTIMORE
- **Principal Investigator:** Flavia Kessler Borges
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,004,029
- **Award type:** 1
- **Project period:** 2022-08-01 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10518429

## Citation

> US National Institutes of Health, RePORTER application 10518429, HIP fracture Accelerated surgical TreaTment And Care tracK-2 (HIP ATTACK-2) trial (1U01AR080377-01A1). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/10518429. Licensed CC0.

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