PROJECT SUMMARY/ABSTRACT: Administrative Core The leadership of the Vanderbilt University Medical Center TBEL Center builds on an existing multidisciplinary team that has been working together for over 15 years on the Vanderbilt-Ingram Cancer Center (VICC) GI Special Programs of Research Excellence (SPORE), as well as the Human Tissue Atlas Network (HTAN) that has been in existence for four years. We have also recruited Dr. Cynthia Sears from Johns Hopkins to round out expertise for this application. Each team member also has extensive experience in collaborative research efforts across multiple studies and multiple institutions. The Administrative Core will provide the primary scientific oversight for the Vanderbilt TBEL activities. It will have primary management and oversight responsibility for all TBEL activities, which include reviewing and regulating financial expenditures, creating and preparing necessary reports, internal and external communications, research coordination, and ensuring compliance with all federal regulations and reporting requirements (including NIH public access policy). Thus, the Administrative Core directly supports all members and organizational components of the TBEL Center, including the three Projects and the two Cores - the Human Pre-Cancer Models (HPM) Core and the Quantitative Bioscience Core (QBC). The Administrative Core will coordinate collaborations with NCI and other TBEL Centers. Our team has extensive experience working within NCI-funded networks. As the funded TBEL Centers are developed, there will be multiple opportunities to find shared aims and potential new collaborative projects in which the Vanderbilt TBEL will enthusiastically participate and even lead. The Administrative Core will also ensure full compliance with the data and resource sharing plans agreed upon with NCI and the TBEL Centers. This will be accomplished by working closely with the QBC to ensure that all relevant data and tools are transferred securely and in a timely manner to the TBEL data coordinating center. During the initial development of the TBEL Center, the Project and Core Leads and Co-Leads will work closely with NCI and the other TBEL Centers. Based on our past experience and present shared vision, we are fully committed to the success of the TBEL Center.