# The stromal microenvironment as a co-organizer of bladder carcinogenesis  and progression

> **NIH NIH U54** · CEDARS-SINAI MEDICAL CENTER · 2022 · $367,880

## Abstract

CORE B ABSTRACT
Core B [Spatial Transcriptomics/Proteomics & Bioinformatics Core] will serve as a centralized supporting hub to
provide service for i) retrospective collection of NMIBCs and clinical outcome, as well as prospective collection
of NMIBCs, ii) spatial transcriptomics and bioinformatics analysis, to assist the three Projects in achieving their
individual and common goals, i.e., to investigate the stromal microenvironment as a co-organizer for bladder
carcinogenesis and progression, and iii) full commitment to early tissue dissemination and data sharing. The
Core has the following aims: Aim 1: Collection of human NMIBCs and clinical outcome, for centralized
distribution. Aim 2: To generate a comprehensive spatial map of bladder cancer tumor microenvironment (TME).
Aim 3: Dissemination of tissues collected, or data generated from aim 1-3 for the research community. The
centralized operation in Core B is specifically organized and designed to maximize its output by supporting
complementary aims from Project 1, 2, and 3 to provide a comprehensive spatial map of the human bladder
tumor and stromal microenvironment, with emphasis in early lesions. Centralized tissue collection and data
generation, followed by pathologic and bioinformatic analyses will provide a streamlined process to visualize the
bladder TME and its relationship to progressor vs non-progressor MIBC patients.

## Key facts

- **NIH application ID:** 10519085
- **Project number:** 1U54CA274375-01
- **Recipient organization:** CEDARS-SINAI MEDICAL CENTER
- **Principal Investigator:** Michael Stanley Lewis
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $367,880
- **Award type:** 1
- **Project period:** 2022-09-22 → 2022-12-20

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10519085

## Citation

> US National Institutes of Health, RePORTER application 10519085, The stromal microenvironment as a co-organizer of bladder carcinogenesis  and progression (1U54CA274375-01). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10519085. Licensed CC0.

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