# Prolonged Normothermic Ex vivo Heart Perfusion (NEVHP)

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $776,002

## Abstract

ABSTRACT
The goal of this project is to establish routinely successful prolonged normothermic ex vivo heart perfusion
(NEVHP) leading to organ banks. We have demonstrated routinely successful ex vivo heart perfusion for 24-72
hours using plasma exchange with a paracorporeal animal, then fresh plasma alone, then continuous
hemofiltration in sheep and pigs. The experiments proposed in this application are planned to determine the
factors responsible for prolonged NEVHP and demonstrate routine 3-day successful ex vivo perfusion. This
would allow heart treatment, verifying heart function, near perfect matching, increase donors, and make heart
transplantation elective. In addition, the NEVHP protocols and systems will be tested to resuscitate hearts after
prolonged periods of cold ischemia and hearts from DCD. Critical step prior translated the animal models into
clinical practice. Lessons from the research with hearts will apply to other organs.

## Key facts

- **NIH application ID:** 10519132
- **Project number:** 1R01HL161139-01A1
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Robert H. Bartlett
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $776,002
- **Award type:** 1
- **Project period:** 2022-09-01 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10519132

## Citation

> US National Institutes of Health, RePORTER application 10519132, Prolonged Normothermic Ex vivo Heart Perfusion (NEVHP) (1R01HL161139-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10519132. Licensed CC0.

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