Abstract: The HCTB Core will assist Junior Principal Investigators (JPIs) with the application of their promising research to the field of clinical viral oncology through prioritization of clinical data and biospecimen collection for JPIs in Phase 2 of Center for Translational Viral Oncology (CTVO). The CTVO will support personnel in the Core who will provide services to the JPIs at reduced/no cost. Consistent with the articulated theme of Phase 2 CTVO, the HCTB, organized and directed by Drs. Subbiah and Bonstaff, collects biospecimens from the HIV/AIDS Malignancy Program and from other oncology clinics that evaluate, diagnose and treat patients with viral associated malignancies. These patients are disproportionately minorities, mostly African American. The overarching goal of HCTB is to assist JPIs with performance of high-quality translational research utilizing linked biospecimens and clinical data from patients receiving care at the University Medical Center - Infectious Diseases Center (UMCNO-IDC) and its affiliated partner, HIV/AIDS Malignancy Program. Use of de-identified human samples will inform and ensure clinical relevance of mechanistic studies and promote clinical translation. Through this effort, we seek to improve health outcomes for underserved HIV+ patients at risk for virus-associated cancers. In addition, access to these unique samples provides JPI's with a competitive edge as they apply for independent grant funding. The HCTB Core will support proposed by JPI research through the following Specific Aims: 1) To expand a HIV outpatient clinic-based system for collection of linked clinical data and biospecimens from HIV+ patients in New Orleans who are at high risk for virus-associated cancers; 2) To ensure storage of high-quality HIV+ biospecimens for easy access by JPIs; 3) To perform timely delivery/shipment of HIV+ biospecimens to internal and external collaborators; 4) To promote collaboration between JPIs and the staff of the Louisiana Tumor Registry (LTR) at LSU School of Public Health to provide access to updated epidemiologic data and analyses on the distribution of viral tumors in underserved minority populations in our State. Funding to the CTVO will support personnel employed within the Core and allow services to be provided at reduced cost to the JPIs while also providing for institutional ethical compliance and insuring protection of human subjects and their privacy. Leveraging involvement of several Centers and Programs at LSUHSC ensures ongoing support and function of this Core following conclusion of the COBRE funding.