# Defective mitochondria-lysosome contact formation and tethering in disease

> **NIH NIH R00** · NORTHWESTERN UNIVERSITY · 2022 · $56,133

## Abstract

PROJECT SUMMARY
Lysosomes and mitochondria are essential organelles for maintaining neuronal homeostasis, and defects in their
function and dynamics have previously been linked to multiple neurodegenerative diseases. In contrast, whether
these two organelles undergo bidirectional crosstalk to contribute to disease pathogenesis is not well understood.
Mitochondria-lysosome contact sites allow for this bidirectional regulation to modulate their network dynamics,
motility and function. Thus, investigating the dynamics of mitochondria-lysosome contacts may provide new
insights into their regulation and their roles in the etiology of neurodegenerative disorders. This research project
uses advanced microscopy techniques to elucidate how defects in mitochondria-lysosome contact tethering
dynamics and formation may contribute to neurodegenerative diseases. Importantly, these studies will help to
highlight new cellular pathways contributing to neurodegeneration in different neurological disorders.

## Key facts

- **NIH application ID:** 10521528
- **Project number:** 3R00NS109252-04S2
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** Yvette Wong
- **Activity code:** R00 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $56,133
- **Award type:** 3
- **Project period:** 2018-09-30 → 2023-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10521528

## Citation

> US National Institutes of Health, RePORTER application 10521528, Defective mitochondria-lysosome contact formation and tethering in disease (3R00NS109252-04S2). Retrieved via AI Analytics 2026-06-15 from https://api.ai-analytics.org/grant/nih/10521528. Licensed CC0.

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