# Mental Health in Autistic Adults:  And RDoC Approach

> **NIH NIH P50** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2022 · $216,592

## Abstract

ABSTRACT- Project 1
Suicide rates in autistic adults are alarming high in recent research; 4- 72% have endorsed suicidal ideation
and 4-33% have engaged in suicidal behavior or attempts. Both scientific and advocacy groups have endorsed
research for effective suicidality assessment and identification of risk factors. However, existing suicidality
screening measures do not seem to function in the same way for autistic adults, and to date, no research has
used a measure of suicide risk rather than a screen of imminent risk. Adaptation of existing suicide screens
may be insufficient, given evidence that autistic adults may have unique risk factors, such as camouflaging of
autistic traits and autistic burnout. This study will develop a suicidality measure for autistic adults, the Autism
Suicidality Inventory, that will capture a continuum of suicide risk. Autistic adults and their allies will refine an
item pool, and 25 autistic adults (at least 10 of which with suicidality) will complete cognitive interviews of the
drafted items to ensure clarity and comprehension. A sample of 1000 autistic and non-autistic adults will
complete the drafted questionnaire and a related online battery of measures to evaluate the dimensionality of
the item pool, conduct Item Response Theory calibration, and compare existing suicide measures to the
proposed questionnaire via IRT co-calibration. A subsample of 300 autistic and non-autistic participants (the
ACE core sample) will repeat the measure every two months for a year, and cross-project analyses will
examine whether those who report more suicidality baseline also report more suicidal ideation in daily life,
model suicide risk over time via latent growth models, and identify factors that are most strongly associated
with suicidality trajectories. The Autism Suicidality Inventory will be the first validated suicide propensity
measure developed for ASD, designed with input from autistic adults and capturing a continuum of risk via an
emphasis on processes that relate to risk. The availability of such a measure is essential to inform intervention
development to improve safety and quality of life.

## Key facts

- **NIH application ID:** 10523167
- **Project number:** 1P50MH130957-01
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Carla A Mazefsky
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $216,592
- **Award type:** 1
- **Project period:** 2022-09-06 → 2027-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10523167

## Citation

> US National Institutes of Health, RePORTER application 10523167, Mental Health in Autistic Adults:  And RDoC Approach (1P50MH130957-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10523167. Licensed CC0.

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