# Modeling Histone Demethylase Function in Neurogenesis

> **NIH NIH R21** · UNIVERSITY OF WISCONSIN-MADISON · 2022 · $414,305

## Abstract

ABSTRACT
Cortical development is dependent on the coordinated expression of critical genes for proper cognitive
function. Alterations in expression of these key genes during development can result in complex
neurological diseases. Epigenetic mechanisms dynamically regulate expression of key genes and their
loss of function disrupts cortical development and contributes to brain disorders. Rare pathogenic
mutations in one epigenetic factor, KDM3B, are linked to intellectual disability and autism spectrum
disorders (ASD). This exploratory proposal will test the functional consequences of these KDM3B
mutations on cortical development using human embryonic stem cells with mutations of KDM3B. We
will investigate both cellular and molecular differences between mutant and control cells as they
differentiate into neural progenitor cells and neurons. Integration of these cellular data with molecular
data will reveal the direct effects of intellectual disability related mutations in KDM3B to
neurodevelopment.

## Key facts

- **NIH application ID:** 10527660
- **Project number:** 1R21NS125121-01A1
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **Principal Investigator:** ANITA BHATTACHARYYA
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $414,305
- **Award type:** 1
- **Project period:** 2022-07-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10527660

## Citation

> US National Institutes of Health, RePORTER application 10527660, Modeling Histone Demethylase Function in Neurogenesis (1R21NS125121-01A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10527660. Licensed CC0.

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