Project Summary (Abstract) Diabetes self-management (DSM) interventions have struggled to deliver relevant, effective, and sustainable support for at-risk adults with diabetes to improve key DSM behaviors, become more activated participants in healthcare, and reduce diabetes complications. One largely untapped resource for this support is patients’ family and friends. Three out of four adults with diabetes reach out to an unpaid family member or friend (a ‘family supporter’) for ongoing help with diabetes management. However, diabetes management interventions to date lack structured and effective approaches to directly engage patients’ family members in supporting successful diabetes management. The long-term goal of this research is to produce structured and evidence- based approaches that engage family supporters in helping at-risk adults initiate and sustain effective diabetes management behaviors. The objective of this study is to compare the effectiveness of a novel program— Family Partners for Health Action (FAM-ACT)—to more traditional, individual patient-focused diabetes self- management education and care management (I-DSME/CM). FAM-ACT uses three innovative approaches to enhance the impact of family support on diabetes management: 1) provide family members core behavioral strategies directed at specific roles in supporting diabetes medical and lifestyle management, 2) teach family members how to deliver support in patient-autonomy supportive ways, and 3) teach family supporters ways to boost patients’ activated participation in healthcare. Community Health Workers (CHWs) will deliver FAM-ACT to patient-family supporter dyads at an urban federally qualified health center. 268 patients with type 2 diabetes and either poor glycemic or blood pressure control, together with a family supporter, will be randomized to receive either FAM-ACT or CHW-led I-DSME/CM over 6 months. The specific aims of this study are to 1) Determine the effect of FAM-ACT on patients’ diabetes health outcomes compared to I-DSME/CM, 2) Determine the effect of FAM-ACT on patient health behaviors and perceived support compared to I-DSME/CM, and 3) Determine the sustainability of health outcomes and health behavior gains made in FAM-ACT compared to I-DSME/CM. The main diabetes health outcome is change from baseline to 6 months in Hemoglobin A1c. Patient behavioral outcomes will include diabetes self-management behaviors, and perceived social support and autonomy supportiveness from family. Sustainability will be assessed at 12 months, after a period of 6 months without CHW intervention. This project is significant because it builds on prior CHW and peer support models to help at-risk diabetes patients with few resources achieve and sustain core health behaviors that underlie successful management of multiple risk factors for diabetes complications. Ultimately, this study will have a positive impact by producing a novel, scalable, evidence-based protocol and tools that lev...