# Genetic Architecture of Alzheimer’s disease Proteinopathies

> **NIH NIH R01** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2022 · $317,786

## Abstract

This is a collaborative study between leading experts in the field to extend our ongoing efforts to
delineate the complete genetic basis of the two AD-specific proteinopathies (Aβ and pathologic tau) by
whole genome sequencing (WGS) using well-characterized and large amyloid-PET and CSF Aβ42/tau
datasets with clinical outcomes of dementia followed by testing the effects of identified significant
variants on downstream neurodegeneration markers, and performing extensive bioinformatics and
functional studies. The primary objective of this application is to perform and analyze WGS in
adequately powered large discovery samples with well-characterized Aβ and tau data along with clinical
outcomes of dementia to identify putative functional variants associated with Aβ and tau pathologies.

## Key facts

- **NIH application ID:** 10532581
- **Project number:** 3R01AG064877-02S1
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Carlos Cruchaga
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $317,786
- **Award type:** 3
- **Project period:** 2021-04-15 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10532581

## Citation

> US National Institutes of Health, RePORTER application 10532581, Genetic Architecture of Alzheimer’s disease Proteinopathies (3R01AG064877-02S1). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10532581. Licensed CC0.

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