# Neurodevelopment of Emotional Interference Resistance in Adolescence to Adulthood: A Multimodal Neuroimaging Approach > **NIH NIH R01** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2022 · $745,644 ## Abstract Project Summary Childhood trajectories of high or increasing internalizing and externalizing symptoms appear to mutually re- enforce one each other and be associated with the emergence and exacerbation of pathology in early adolescence and early adulthood. They have been linked with alterations in neural networks underlying emotional interference resistance—the ability to sustain attention on goal-relevant information while resisting interference from irrelevant emotional stimuli. Although, these neural networks undergo maturational changes during adolescence, their development in relation to improvements in emotional interference resistance has yet to be well characterized. Examining neural activity to emotional distracters during working memory provides rich information about the temporal sequence of emotional interference resistance. Emotional distracters recruit an extended affective visual system (AVS) comprised of the occipital-temporal cortex, medial temporal lobe/amygdala, ventrolateral (vl), ventromedial (vm), and dorsomedial (dm) prefrontal cortex (PFC); and modulate early neural activity within the AVS, as evidenced by greater magnitude of event-related potentials (ERPs) (i.e., N1, P1, and LPP). The vlPFC and vmPFC and their connections to the amygdala, facilitated by the uncinate fasciculi (UF) white matter tracts, play a central role in emotional interference resistance. What remains unclear is how development of AVS regions as well as the structural and functional connectivity within the AVS promotes emotional interference resistance and contributes to trajectories of psychopathology common to internalizing and externalizing disorders. We address these questions through the following Aims: 1) characterize the neurodevelopment of emotional interference resistance in adolescence through adulthood; 2) characterize the neurodevelopment of the temporal dynamics of neural activity during processing of emotional distracters; 3) examine how deviations in neurodevelopment of emotional interference resistance create a vulnerability to life stress to predict increasing trajectories of internalizing/externalizing symptoms; and (4) characterize relationships among developmental changes in multimodal neuroimaging indices and trajectories of internalizing/externalizing symptoms. We will recruit a sample of 210 10-25 year-olds (78% White, 13% Black, 4% Asian, 2% Latinx, 3% Multiracial) in an accelerated longitudinal design, with 30 participants (50%M/F, 2/3 at high risk based on parental diagnosis of an internalizing and/or externalizing disorder and elevated current internalizing and/or externalizing symptoms) in each age range (10-11, 12-13, 14-15, 16-17, 18-19, 20-22, and 23- 25) followed longitudinally every 9 months to provide five assessments of internalizing and/or externalizing symptoms, and every 18 months to provide three neural assessments. We will use multimodal neuroimaging to investigate the neurodevelopment of resisting emotional int... ## Key facts - **NIH application ID:** 10533518 - **Project number:** 1R01MH128229-01A1 - **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH - **Principal Investigator:** Neil Patrick Jones - **Activity code:** R01 (R01, R21, SBIR, etc.) - **Funding institute:** NIH - **Fiscal year:** 2022 - **Award amount:** $745,644 - **Award type:** 1 - **Project period:** 2022-09-01 → 2027-08-31 ## Primary source NIH RePORTER: https://reporter.nih.gov/project-details/10533518 ## Citation > US National Institutes of Health, RePORTER application 10533518, Neurodevelopment of Emotional Interference Resistance in Adolescence to Adulthood: A Multimodal Neuroimaging Approach (1R01MH128229-01A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10533518. Licensed CC0. --- *[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*