# Mentoring translational scientists in international infectious disease research

> **NIH NIH K24** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2023 · $191,553

## Abstract

Abstract
 Dr. Greenhouse is a physician scientist trained in internal medicine, infectious diseases, and
biostatistics. His research goals are to advance the understanding of malaria epidemiology, in particular
transmission dynamics and host immunity. To study the complex interplay between malaria parasites, human
and mosquito hosts, and the environment, Dr. Greenhouse's work combines field, laboratory, and advanced
data analysis techniques, including development of novel technological and analytical approaches. There is a
large and growing interest in translational global health research among trainees, particularly clinicians.
However, success in this field requires obtaining a broad skill set and lacks an established training path or the
sufficient availability of appropriate mentors. Dr. Greenhouse has been highly productive in this area of patient
oriented research (POR), as evidenced by his publication record and portfolio of funded research. He is
dedicated to mentoring the next generation of scientists, but lacks dedicated time for mentoring or career
development. In this application, Dr. Greenhouse outlines his qualifications in performing high quality POR and
track record in mentoring successful trainees. He presents a plan for improving the quality and quantity of his
mentoring, including formal training in mentorship, developing a structured mentorship plan, and recruiting
talented trainees from a large pool of candidates, including infectious diseases fellows and clinicians from
resource limited settings. He will also use protected time to build advanced skills in sequencing, bioinformatics,
and population genetics. Dr. Greenhouse ultimately plans to develop a center of excellence (with the support of
his division) in molecular and computational infectious disease epidemiology in order to advance
interdisciplinary training and accelerate research in this area.
 Dr. Greenhouse's existing research portfolio provides a wealth of opportunities for trainees in 3 related
areas of translational malaria research: genetic epidemiology to track malaria transmission and geographical
spread, novel serologic assays of P. falciparum exposure for improved surveillance in control and elimination,
and the epidemiology of P. falciparum infection and immunity. In addition, Dr. Greenhouse proposes to
augment his POR with 3 novel aims to be supported by this K24 award, leveraging the highly successful East
African International Center of Excellence in Malaria Research (ICEMR) study, funded by the NIH for another 6
years: 1) to develop sequencing-based platforms for comprehensive characterization of P. falciparum antigenic
variation and the host antibody response; 2) to determine how antibody responses develop in response to
natural P. falciparum infection, and how pre-existing and evolving responses are associated with clinical
outcomes of these infections; and 3) to determine whether P. falciparum infections acquired during travel are
different in terms...

## Key facts

- **NIH application ID:** 10534671
- **Project number:** 5K24AI144048-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Bryan R Greenhouse
- **Activity code:** K24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $191,553
- **Award type:** 5
- **Project period:** 2019-01-22 → 2023-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10534671

## Citation

> US National Institutes of Health, RePORTER application 10534671, Mentoring translational scientists in international infectious disease research (5K24AI144048-05). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/10534671. Licensed CC0.

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