# Activity-Dependent Mechanisms of Memory Consolidation

> **NIH NIH R01** · STANFORD UNIVERSITY · 2023 · $589,457

## Abstract

PROJECT SUMMARY
Vision is an active sense, with eye movements powerfully shaping the acquisition of visual
information about the world. This project investigates how motor learning adjusts the neural
circuitry controlling eye movements, to maintain the accuracy of eye movements over short and
long time scales. The specific focus of the research is to understand how oculomotor learning,
i.e., improvement of the accuracy of eye movements through experience, is transferred from
short-term to long-term storage. This consolidation process occurs, not only for motor skills like
eye movements, but is a general feature of learning and memory systems. Some memories,
including oculomotor memories, are transformed during the time after the initial acquisition of the
memory, in a way that renders older, consolidated memories independent of brain areas that are
critical for newer memories. This process, known as systems consolidation, is thought to depend
on activity of neurons in the brain area initially critical for the memory, and the hypothesis is that
this activity induces changes in the brain area(s) supporting long-term storage of the memory.
The proposed research characterizes the nature of the neural signals transmitted between brain
areas supporting memory at different times after their acquisition, and the rules that operate on
those neural signals to implement stable transfer of a memory from one brain area to another.

## Key facts

- **NIH application ID:** 10534735
- **Project number:** 5R01EY031972-03
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** MARK S GOLDMAN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $589,457
- **Award type:** 5
- **Project period:** 2021-01-01 → 2025-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10534735

## Citation

> US National Institutes of Health, RePORTER application 10534735, Activity-Dependent Mechanisms of Memory Consolidation (5R01EY031972-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10534735. Licensed CC0.

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