PROJECT SUMMARY/ABSTRACT Healthcare has entered an unprecedented time when rapid sensing of large amounts of data and processing of that data yields information about human health and disease that was unattainable just several years ago. This was accelerated by the pandemic, where measurement sciences was at the frontline of the COVID-19 response with rapid genetic, antigen or antibody tests. This demand for measurement science and bioanalysis will continue, requiring an educated workforce of practitioners and researchers who can use this information to solve the world's challenges in human health and disease crucial to positive outcomes in healthcare. As such, with rapid advances in biology, genetic and protein analyses, and computational design and assessment, together with low-cost manufacturing processes, electronic devices, and novel materials and nanotechnology, there exists an unmet demand for a forum for in-depth discussions and interactions between investigators at the forefront of these fields, working to solve the world's challenges in health-centered sensing. The 2022 Bioanalytical Sensors GRC seeks to fulfill this need in an intimate and scholarly setting. The broad, long-term goal of this application is a sustainable Bioanalytical Sensors Gordon Research Conference (BAS- GRC)/Gordon Research Seminar (GRS) culture that is forward-thinking in its approach to solving difficult biomedical measurement and analysis challenges. In this highly interdisciplinary conference, the week will progress through cutting-edge topics that span from the smallest nanoscale elements in molecular recognition and intracellular sensing, to human scale wearable/implantable devices, to large scale environmental monitoring in agriculture and our environment. The audience for this conference is from many research backgrounds, including engineering, chemistry and physics, to life sciences and agriculture. Participants from industry, entrepreneurs, clinicians, and practitioners are an integral part of translating cutting-edge technology into the field. Students, young investigators, and established experts will come together with them to discuss the latest challenges and opportunities in sensing and analytics at the interface between biology and devices. This conference will have a direct impact on the Mission and Goals of the NIH, especially the NIBIB. The Aims and Objectives of the 2022 BAS-GRC/GRS target the integration of investigators in the physical and engineering sciences with the life science community to solve difficult problems with improving human health. Research discussion will focus on: single molecule resolution measurements, wearable/implantable devices, sensing in the brain, new technologies for rapid pathogen detection and identification, health diagnostics, and monitoring of a healthy environment to foster better nutrition, access to clean water, and air. Finally, data- intensive assessment tools dovetail into all these areas and thus has the ...