ABSTRACT The Don S. Fredrickson Lipid Research Conference (FLRC) brings together scientists and trainees investigating the impact of lipid and lipoprotein metabolism on the development and treatment of Cardiometabolic Disease. The FLRC is named after the late Don S. Fredricks who as the director of the National Heart Institute (now the NHLBI) from 1966 – 1974 and later the NIH, developed the clinical classification for dyslipidemias (Type I-V), described Tangier’s Disease, and made seminal discoveries in lipoprotein metabolism. Most importantly, he trained both basic and clinical scientists and practitioners who have had a tremendous impact on the field of lipoprotein metabolism. Since 2016 the FLRC has employed a rotating institutional host model, the first of which was held at the University of Kentucky in conjunction with the Saha Cardiovascular Research Center Research Day. The FLRC has since been hosted by Vanderbilt University, the University of Cincinnati. The 2022 conference will be hosted by Duke University and the University of North Carolina in conjunction with the North Carolina Diabetes Research Day. The FLRC will be hosted by Vanderbilt University in 2023 and the Medical College of Wisconsin in 2024. Keynote Lectures at the 2022 Fredrickson conference include Karen Mohlke, University of North Carolina and Deborah Muoio, Duke University on Days 1 and 3 of the conference. The scientific sessions include Novel Models in Lipid Metabolism, Adipose Tissue, Lipoprotein Metabolism, and Lipids and Body Composition. Day 2 of the conference will be sponsored by the North Carolina Diabetes Research Center. The agenda includes additional scientific sessions; multiple “Poster Pitch” sessions (5-7, 90-second presentations by trainees) and two judged poster sessions. The FLRC places a strong emphasis students and fellows, early career faculty, and underrepresented groups. The combined agenda affords every trainee in attendance the opportunity to present their research on stage, network with leaders in the field, and broaden their scope and understanding of research in lipid metabolism and Cardiometabolic Diseases. Our format encourages informal interactions between scientists at all levels, providing an innovative approach to the exchange of ideas and synthesis that will move the field of lipid research forward. The conference will have high impact as the program spans basic science discovery to clinical significance. It is therefore expected that the meeting will provide new insights not only into basic aspects of lipid metabolism, but also how to treat, and ultimately cure, a wide variety of Cardiometabolic Disease states.