Abstract We will convene the third annual Interdisciplinary Nutrition Sciences Symposium (INSS), entitled “Diet and Chronic Unresolved Inflammation: Implications for Obesity-Associated Complications.” This conference will address the critical need to establish rigorous interdisciplinary and translational approaches in the context of diet and nutrition to effectively prevent and treat chronic inflammation associated with metabolic diseases. Interactive discussions will enable early career investigators and faculty from populations underrepresented in science to engage with senior investigators, and for academic and industry scientists to collaborate. These highly valuable experiences will provide early career investigators and trainees with a foundation upon which they will be able to contribute to the next generation of successful inflammation and nutrition research. Confirmed and invited speakers include leading national academic scientists from diverse backgrounds with expertise in inflammation and translational obesity and nutrition/diet research. The four interactive sessions are organized to facilitate and encourage integration across disciplines, synthesize knowledge, and generate new ideas in selected areas of innate/adaptive immunity and inflammation, nutrition (including precision nutrition), and obesity. A major goal of the conference is to build on the dialogue we began in our successful 2019 and 2021 symposia to develop best practices for translational science and to generate ideas for proposals and collaborative projects. In addition, we will feature a networking lunch and a session devoted to academic-industry partnership to encourage discussion across scientific approaches, seniority, and industry/academia ties. We will also hold an early career lunch and workshop to allow opportunities for detailed discussions around mentoring and career development. Rigorous evaluation of the symposium will involve summative assessment activities through online surveys conducted via the conference website to assess what participants learned, what was effective, and what needs improvement. An anticipated deliverable of the INSS is a scientific paper geared towards a major immunology or nutrition journal on how to translate findings from basic and clinical studies toward preventing and improving chronic unresolved inflammation based on rigorous evidence. We will promote the symposium broadly via the American Association of Immunologists, Society for Leukocyte Biology, American Society for Nutrition, patient support groups such as the Obesity Action Coalition, nutrition departments, immunology departments, and Nutrition Obesity Research Center networks. We anticipate that attendees will span the diverse fields of immunology, nutrition, physiology, bioinformatics, biochemistry, and more. We anticipate attendance of approximately 100 scientists, based on the success of the two last two symposia and the outstanding leading keynote speakers who have agr...